CETP Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1050
PA1-050 detects cholesteryl ester transfer protein (CETP) from human tissues. PA1-050 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~70 kDa band from human liver extracts representing CETP. The PA1-050 immunogen is a synthetic peptide corresponding to residues C D(149) S G R V R T D A P D(159) of human CETP protein.This peptide (Cat. No. PEP-209) is available for use in neutralization and control experiments.It has been proposed that high density lipoproteins (HDLs) function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to specifically accelerate the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determit of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. In general, elevated levels of CETP have been associated with increased risk of coronary heart disease.
|Synthetic peptide corresponding to residues C D(149) S G R V R T D A P D(159) of human CETP protein.|
|Antigen affinity chromatography|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|Cholesteryl Ester Transfer Protein, Lipid transfer protein I|
|-20° C, Avoid Freeze/Thaw Cycles|
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