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CFHR5 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA525595

Catalog No. PIPA525595

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

CFHR5 is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).
Specifications

Specifications

CFHR5
Polyclonal
PBS with 0.09% sodium azide
Q9BXR6
CFHL5, FHR-5, FHR5, complement factor H-related protein 5, factor H-related protein 5
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
81494
Flow Cytometry, Immunohistochemistry, Western Blot
Unconjugated
CFHR5
Liquid
CFHR5
KLH conjugated synthetic peptide between 203-231 amino acids from the central region of human CFHR5
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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