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cGB-PDE Mouse anti-Rat, Unlabeled, Clone: 54, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611499

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Catalog No. BDB611499

This item has been discontinued and is no longer available. Please call customer service for assistance: 1-800-766-7000.



cGMP is involved in nitric oxide signaling, as well as cell signaling associated with natriuretic peptides and guanylins. Intracellular targets for cGMP include cGMP-dependent protein kinase, cyclic nucleotide-gate ion channels, and cGMP-Binding PhosphoDiesterases (cGB-PDE). Tissue levels of cGMP are determined by guanylyl cyclases that catalyze the formation of cGMP and cyclic nucleotide PDEs that catalyze the breakdown of cGMP. In the PDE superfamily PDE2, PDE5, PDE6, and PDE10 have dimeric structures that contain highly cGMP-specific allosteric cGMP binding sites in addition to a phosphodiesterase catalytic site. PDE5 is highly expressed in aorta and lung, but is also expressed in intestine, kidney, adrenal gland, cerebellum, and cerebrum. In the cerebellum, PDE5 is expressed in the Purkinje cell layer during neonatal development. PDE5 is also abundant in vascular smooth muscle cells where it is involved in regulating cGMP levels and vascular smooth muscle tonicity. Thus, PDE5 is important for regulating cGMP levels in both neuronal and non-neuronal tissues that utilize cGMP signaling pathways for the regulation of cell function.

Host Species: Mouse
Clone: 54
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Rat cGB-PDE aa. 2-108
Formula Weight [Chemical]: 85-95kDa

Immunofluorescence, Western Blotting



Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
Western Blot
PDE5; cGMP-Binding PhosphoDiesterases
Affinity Purified
Rat cGB-PDE aa. 2-108
Cell Biology
Product Certifications


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