CHFR Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528079
PA5-28079 targets CHFR in WB applications and shows reactivity with Human samples. The PA5-28079 immunogen is synthetic peptide corresponding to a region within amino acids 602 and 664 of Human CHFR. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the ft.Lys-48 ft.-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of ft.Lys-63 ft.-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at ft.Lys-63 ft. are usually not targeted for degradation, but are rather involved in signaling cellular stress.
|Synthetic peptide corresponding to a region within amino acids 602 and 664 of Human CHFR|
|Antigen affinity chromatography|
|PBS with 40% glycerol and 0.01% thimerosal; pH 7|
|RNF116, RNF196, E3 ubiquitin-protein ligase CHFR, RING finger protein 196, checkpoint with forkhead and RING finger domains protein|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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