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CHFR Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA528079

Catalog No. PIPA528079


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Description

Description

PA5-28079 targets CHFR in WB applications and shows reactivity with Human samples. The PA5-28079 immunogen is synthetic peptide corresponding to a region within amino acids 602 and 664 of Human CHFR. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the  ft.Lys-48 ft.-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of  ft.Lys-63 ft.-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at  ft.Lys-63 ft. are usually not targeted for degradation, but are rather involved in signaling cellular stress.
Specifications

Specifications

CHFR
Polyclonal
Unconjugated
CHFR
Liquid
CHFR
Synthetic peptide corresponding to a region within amino acids 602 and 664 of Human CHFR
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 40% glycerol and 0.01% thimerosal; pH 7
Q96EP1
RNF116, RNF196, E3 ubiquitin-protein ligase CHFR, RING finger protein 196, checkpoint with forkhead and RING finger domains protein
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
55743
Documents
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