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anti-Chk1 Ab-1, Clone: DCS-300, Epredia™ LabVision
Mouse Monoclonal Antibody
Supplier: Epredia MS1513PABX
Description
Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved in these processes as regulators of Cdks. Chk1 and Chk2 both function as essential components in the G2-DNA damage checkpoint by phosphorylating CDC25C in response to DNA damage. CDC25A, CDC25B and CDC25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating CDC2 p34 on regulatory tyrosine residues. Phosphorylation of CDC25C by Chk1 and 2 inhibits its phosphatase activity, thereby blocking mitosis. It has also been shown that Chk1 can phosphorylate Wee1 in vitro, providing evidence that the hyperphosphorylated form of Wee1, seen in cells delayed by Chk1 overexpression, is due to phosphorylation by Chk1.
Host Species: Mouse
Clone: DCS-300
Isotype: IgG2b/κ
Cross Reactivity: Human. Others not known.
Immunogen: Recombinant human Chk1 protein.
Molecular Weight: ∽56kDa
Positive Control: HeLa cells.
Cellular Localization: Nuclear
Western Blotting
Specifications
| Chk1 Ab-1 | |
| 1mg/mL | |
| Mouse | |
| 200 μL | |
| Human | |
| IgG2b κ |
| Monoclonal | |
| Unconjugated | |
| Recombinant human Chk1 protein. | |
| Primary | |
| Purified |
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