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anti-Chk2 Ab-5, Clone: DCS-270, Thermo Scientific Lab Vision

Mouse Monoclonal Antibody

Specifications

Antigen Chk2 Ab-5
Clone DCS-270
Host Species Murine
Isotype IgG2a κ
Monoclonal or Polyclonal Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Conjugate Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Conjugate Price Quantity & Availability  
MS1515PCS
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Epredia
MS1515PCS
5 Slides Unconjugated This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
MS1515R7
View Documents
Epredia
MS1515R7
7mL Unconjugated This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
Description

Description

Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved in these processes as regulators of Cdks. Chk1 and Chk2 both functionas essential components in the G2 DNA damage checkpoint by phophorylating Cdc25C in response to DNA damage. Phosphorylation inhibits Cdc25C activity, thereby blocking mitosis. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. It has also been shown that Chk1 can phosphorylate Wee1 in vitro, providing evidence that the hyperphosphorylated form of Wee1, seen in cells delayed by Chk1 overexpression, is due to phosphorylation by Chk1.

Host Species: Mouse
Clone: DCS-270
Isotype: IgG2a/κ
Cross Reactivity: Human. Others not known.
Epitope: Not determined
Immunogen: Recombinant human Chk2 protein.
Molecular Weight: ~70kDa
Positive Control: HeLa cells. Tonsil.
Cellular Localization: Nuclear

Immunohistochemistry (Formalin/Paraffin), Western Blotting

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly

Specifications

Specifications

Chk2 Ab-5
Murine
Monoclonal
DCS-270
IgG2a κ
Primary
SDS
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