CHMP4B Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA526536
This antibody is predicted to react with chicken, mouse, Xenopus and zebrafish based on sequence homology.CHMP4B is a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies.
|PBS with 0.09% sodium azide|
|C20orf178, CHMP4A, CTPP3, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4, SNF7 homolog associated with Alix 1, Snf7 homologue associated with Alix 1, charged multivesicular body protein 4b, chromatin modifying protein 4B, chromatin-modifying protein 4b, hSnf7-2, hVps32-2, vacuolar protein sorting-associated protein 32-2, vacuolar prote|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|KLH conjugated synthetic peptide between 51-79 amino acids from the N-terminal region of human CHMP4B|
|Antigen Affinity Chromatography, Protein A|
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