Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

CIC Rabbit anti-Canine, Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA146018

Catalog No. PA146018


Add to cart

Description

Description

By Western blot, PA1-46018 is specific for the ~250 kDa CIC protein. CIC (~164 kDa) interacts with Ataxin 1 (~87 kDa). This may explain the band at 250 kDa (complex).Suggested positive control: Hela whole cell extract.

CIC, a human homolog of Drosophila capicua, encodes a high mobility group box transcription factor and is fused to a double homeodomain gene DUX4 as a result of a recurrent chromosomal translocation. It is involved in epidermal growth factor receptor (EGFR) signaling, developmental patterning, and cell fate. In humans, CIC may be involved in granule cell lineage, cerebellar development, and medulloblastoma tumorigenesis. Recent evidence indicates that CIC is involved in Spinocerebellar Ataxia Type 1 (SCA-1) where it interacts directly with the product of the SCA-1 gene Ataxin-1.
Specifications

Specifications

CIC
Polyclonal
Unconjugated
CIC
Liquid
CIC
A synthetic peptide made to a region within residues 1500-1608 of the human Capicua protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Canine, Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
1 mg/mL
PBS with 0.02% sodium azide; pH 7-8
Q96RK0, Q924A2
Capicua , KIAA0306
Rabbit
IgG
0.1 mg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
23152, 308435, 484475, 71722
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit