CIDEB Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520323
A suggested positive control is mouse small intestine tissue lysate. PA5-20323 can be used with blocking peptide PEP-0443.Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE-B induces apoptosis, which is inhibited by DFF45. CIDE-B is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-B is expressed mainly in liver and at lower levels in spleen, kidney, peripheral blood lymphocytes and bone marrow.
|PBS with 0.02% sodium azide|
|cell death activator CIDE-B|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|12684, 27141, 364388|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|A peptide corresponding to 15 amino acids near the carboxy terminus of human CIDE-B.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
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