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CIS Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527128

Catalog No. PIPA527128


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Description

Description

PA5-27128 targets CIS in IF, IHC (P), and WB applications and shows reactivity with Human samples. The PA5-27128 immunogen is synthetic peptide corresponding to a region within amino acids 196 and 258 of Human CIS. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

CIS
Polyclonal
Unconjugated
CISH
Liquid
CISH
Synthetic peptide corresponding to a region within amino acids 196 and 258 of Human CIS
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 20% glycerol and 0.01% thimerosal; pH 7
Q9NSE2, O70512
BACTS2, CIS, CIS-1, G18, SOCS, cytokine-inducible SH2-containing protein, cytokine-inducible inhibitor of signaling type 1B, suppressor of cytokine signaling
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
1154, 83681
Documents
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