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PLEKHO1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520827

Catalog No. PIPA520827


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Description

Description

A suggested positive control is human lung tissue lysate. PA5-20827 can be used with blocking peptide PEP-0941.

CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex. CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha’, and is thought to play a role in targeting CK2alpha to a particular cellular location. CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton. CKIP1 can also interact with other proteins such as ATM, an upstream kinase of p53, and recruit the nuclear ATM to the plasma membrane, suggesting CKIP1 may regulate ATM function through re-localizing ATM. CKIP1 can also form a complex with the kinase AKT, leading to a down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.
Specifications

Specifications

PLEKHO1
Polyclonal
Unconjugated
PLEKHO1
Liquid
PLEKHO1
An 18 amino acid peptide from near the carboxy terminus of human CKIP1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q53GL0, Q9JIY0, Q5BJM5
RP11-458I7.3, CKIP-1, OC120; 2810052M02Rik; C-Jun-binding protein; CK2 interacting protein 1; HQ0024c protein; CK2-interacting protein 1; JBP; OC120; PH domain-containing family O member 1; casein kinase 2-interacting protein 1; osteoclast maturation-associated gene 120 protein; pleckstrin homology domain-containing family O member 1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
310674, 51177, 67220
Documents
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