CLAC-P Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14306
PA1-4306 detects CLAC-P (NC2-1 region) in human and mouse samples. PA1-4306 has been successfully used in Western blot procedures. By Western blot this antibody detects bands of 50, 70, and 100 kDa representing CLAC-P in formic acid extracts of Alzheimer’s disease brain. PA1-4306 immunizing peptide corresponds to amino acid residues 171-183 of the NC2-1 region of human and mouse CLAC-P.Antibodies against senile plaque (SP) amyloid obtained a clone 9D2, which labeled amyloid fibrils in SPs and reacted with approximately 50/100 kDa polypeptides in Alzheimer ft.s disease (AD) brains. The 9D2 antigen was identified as CLAC (collagen-like Alzheimer amyloid plaque component), and its precursor as CLAC-P/collagen type XXV. Both secreted and membrane-tethered forms of CLAC-P/collagen type XXV specifically bound to fibrillized Abeta, implicating these proteins in beta-amyloidogenesis and neuronal degeneration in AD.
|Synthetic peptide: N(171) H G F L S A D Q QL I K(183)|
|Antigen affinity chromatography|
|PBS with 0.02% sodium azide|
|-20° C, Avoid Freeze/Thaw Cycles|
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