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CLAC-P Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14307

Catalog No. PA14307


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Description

Description

PA1-4307 detects CLAC-P (NC2-2 region) in human samples. PA1-4307 has been successfully used in Western blot procedures. By Western blot this antibody detects bands of 50, 70, and 100 kDa representing CLAC-P in formic acid extracts of Alzheimer’s disease brain. PA1-4307 immunizing peptide corresponds to amino acid residues 155-169 of the NC2-2 region of human and mouse CLAC-P.

Antibodies against senile plaque (SP) amyloid obtained a clone 9D2, which labeled amyloid fibrils in SPs and reacted with approximately 50/100 kDa polypeptides in Alzheimer ft.s disease (AD) brains. The 9D2 antigen was identified as CLAC (collagen-like Alzheimer amyloid plaque component), and its precursor as CLAC-P/collagen type XXV. Both secreted and membrane-tethered forms of CLAC-P/collagen type XXV specifically bound to fibrillized Abeta, implicating these proteins in beta-amyloidogenesis and neuronal degeneration in AD.
Specifications

Specifications

CLAC-P
Polyclonal
Unconjugated
COL25A1
Liquid
COL25A1
Synthetic peptide: K(155) G E Q G D Q G P R M V F P K(169)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9BXS0
CLAC, CLACP
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
84570
Documents
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