Claudin 11 Rabbit anti-Human, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA137478
This antibody is predicted to react with mouse based on sequence homology. Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is testis or mouse brain tissue.The claudin superfamily consists of many structurally related proteins in humans. These proteins, which include claudin 1 through 18, are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Claudins, which consist of four trans-membrane domains and two extracellular loops, make up tight junction strands. Claudin-11 is an oligodendrocyte-specific protein that is expressed in the tight junctions of Sertoli cells and myelin sheaths in mice.
|PBS with 1% BSA and <0.1% sodium azide; pH 7.4|
|OSP, OTM, claudin-11, oligodendrocyte transmembrane protein, oligodendrocyte-specific protein|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Immunohistochemistry (Paraffin), Western Blot|
|Synthetic peptide derived from C-terminus of human claudin 11 protein|
|Antigen affinity chromatography|
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