chloride channel 7, Mouse, Clone: 4A3, Abnova™

Mouse monoclonal antibody raised against a partial recombinant CLCN7.

Manufacturer: Abnova Corporation H00001186M01

Catalog No. 89-000-578

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    Formulation In 1X PBS, pH 7.4
    Gene CLCN7
    Gene Accession No. NM_001287
    Gene Alias CLC-7, CLC7, FLJ26686, FLJ39644, FLJ46423, OPTA2, OPTB4
    Gene Symbols CLCN7
    Applications Enzyme Linked Immunosorbent Assay,Western Blotting
    Species Reactivity Human
    Storage Requirements Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
    Gene ID (Entrez) 1186
    Description chloride channel 7
    Antigen chloride channel 7
    Format Affinity Purified
    Host Species Mouse
    Immunogen CLCN7 (NP_001278, 706 a.a. ∽806 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
    Isotype IgG2a
    Purification Method Protein A column
    Quantity 50μg
    Regulatory Status RUO
    Whole Molecule Y
    Primary or Secondary Primary
    Monoclonal or Polyclonal Monoclonal
    Clone 4A3
    Conjugate Unlabeled
    Cross Reactivity Human

    The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. [provided by RefSeq


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