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Claudin 16 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523939

Catalog No. PIPA523939


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Description

Description

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28.
Specifications

Specifications

Claudin 16
Polyclonal
PBS with 0.09% sodium azide
Q9Y5I7
HOMG3, PCLN1, PCLN-1, claudin-16, hypomagnesemia 3, with hypercalciuria and nephrocalcinosis, paracellin-1
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
10686
Flow Cytometry, Immunohistochemistry, Western Blot
Unconjugated
CLDN16
Liquid
CLDN16
KLH conjugated synthetic peptide between 6-33 amino acids from the N-terminal region of human CLDN16
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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