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Caspase 9 (Cleaved Asp315) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA517913

Catalog No. PIPA517913


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Description

Description

It is not recommended to aliquot this antibody. This antibody was orginally validated as part of a Thermo Scientific Cellomics High Content Screening Kit. The antibody sold separately may have slightly different performance and may need to be further optimized for the best results.

Caspase 9 (ICE-like apoptotic protease 6, ICE LAP6, apoptotic protease Mch6, apoptotic protease activating factor 3, Apaf3) is a member of the peptidase family C14 that contains a CARD domain. Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspase 9 is active as a heterotetramer, is present in the cytosol and, upon activation, translocates to the mitochondria. Caspase 9 is involved in the caspase activation cascade responsible for apoptosis execution and cleaves/activates Caspase 3 and Caspase 6. Further, Caspase 9 is involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Caspase 9 promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner, and proteolytically cleaves poly(ADP- ribose) polymerase (PARP). Caspase 9 is expressed in variety of human tissues. An isoform of rat Caspase-9 has been identified in which the C terminus of full-length Caspase-9 is replaced with an alternative peptide sequence. Mutations in Caspase 9 affect brain development. In mice, insufficient Caspase 9 have resulted in abnormal cerebrum development and neuron development. In humans, dysfunctional Caspase 9 expression vary from tissue to tissue. Low levels of Caspase 9 may play a role in cancer development and neurodegenerative diseases such as Alzheimer’s Disease (AD).
Specifications

Specifications

Caspase 9 (Cleaved Asp315)
Polyclonal
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
P55211
CASP-9; ICE-like apoptotic protease 6; OTTHUMP00000002324; apoptotic protease MCH-6; apoptotic protease activating factor 3; apoptotic protease-activating factor 3; caspase 9, apoptosis-related cysteine protease; caspase-9; cas9
Rabbit
IgG
100 μL
-20°C
Primary
842
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Unconjugated
CASP9
Liquid
CASP9
Synthetic peptide corresponding to residues surrounding Asp315 of human caspase-9
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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