CLIP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520545
A suggested positive control is rat brain tissue lysate. PA5-20545 can be used with blocking peptide PEP-0665.CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin’s disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.
|A 17 amino acid peptide from near the carboxy terminus of human CLIP170.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|P30622, Q922J3, Q9JK25|
|CLIP, CLIP-170, CLIP170, CYLN1, RSN; CAP-Gly domain-containing linker protein 1; cytoplasmic linker protein 1; cytoplasmic linker protein 170 alpha-2; cytoplasmic linker protein CLIP-170; restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|56430, 6249, 65201|
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