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CLOCK Rabbit anti-Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1521

Catalog No. PA1521

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein-mediated, autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-ARNT3 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila per. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.

PA1-521 detects CLOCK from cells transfected with the mouse CLOCK gene.PA1-521 has been sucessfully used in Western blot procedures. By Western blot, this antibody detects an ~100kDa protein representing CLOCK from cells transfected with the mouse CLOCK gene.The PA1-521 immunogen is a synthetic peptide corresponding to residues C S(394) L P E T A A D K S Q D S G S D N (410) of mouse CLOCK. This sequence is completely conserved between mouse and human CLOCK. PA1-521 immunizing peptide (Cat. # PEP-073) is available for use in neutralization and control experiments.
Specifications

Specifications

CLOCK
Polyclonal
Unconjugated
Clock
Liquid
CLOCK
Synthetic peptide corresponding to residues C S(394) L P E T A A D K S Q D S G S D N (410) of mouse CLOCK.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Mouse
Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
O08785
Circadium Locomotor Output Cycles Kaput
Rabbit
IgG
200 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
12753
Documents
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