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Clostridium tetani Tetanus Toxin, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA186193

Catalog No. PA186193

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Tetanus toxin is a neurotoxin produced by the vegetative spore of Clostridium tetani. The toxin causes tetanus, a disease that is characterised by prolonged contraction of skeletal muscle. World-wide, approximately 1 million cases of tetanus occurs annually, resulting in approximately 300,000 to 500,000 deaths, mostly in developing countries. The tetanus toxin has a molecular weight of approximately 150kDa and consists of a heavy chain (B-chain, 100kDa) and a light chain (A-chain, 50kDa) that are connected by a disulfide bond. The toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits the release of the neurotransmitters GABA and glycine by synaptobrevin-2. This results in overactivity in the muscle. The binding of the toxin to neurons is irreversible.

Specifications

Specifications

Clostridium tetani Tetanus Toxin
Polyclonal
Unconjugated
Purified
tetX
Purified tetanus toxin.
Purified
RUO
Antibody
Polyclonal
Immunoprecipitation
4mg/mL
PBS with 0.1% sodium azide
C. tetani, Tetanus Toxin
Goat
IgG
1mL
Store at 4°C or Store at -20°C if preferred
Primary
Bacteria
Documents
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