CNOT4 Rabbit anti-Bovine, Chicken, Human, Mouse, Rat, Xenopus laevis, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523243
DescriptionCNOT4 is a 575 amino acid protein with E3 ubiquitin ligase activity, mainly involved in protein modification and protein ubiquitination. It contains a ring type zinc finger domain of the C4C4 type, an RNA recognition motif and a bipartite nuclear localization signal. Studies show that CNOT4 is a component of the CCR4-NOT (CAF1) core complex that functions as general transcription regulation complex and has both a positive as well as a negative effect on the transcription of multiple functionally unrelated genes, thus controls gene expression. CNOT4 interacts with CNOT1 via C-terminus and with E2 ubiquitin ligases via C4C4 RING domain. Reports suggest that CNOT4 gets phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR.
|Synthetic peptide (68 KPLSQEELQRIKNEKKQK 85) of CNOT4 protein.|
|Antigen affinity chromatography|
|Bovine, Chicken, Human, Mouse, Rat, Xenopus laevis|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% BSA and 0.05% sodium azide|
|CLONE243, NOT4, NOT4H, CCR4-NOT transcription complex subunit 4, CCR4-associated factor 4, E3 ubiquitin-protein ligase CNOT4, NOT4 (negative regulator of transcription 4, yeast) homolog, potential transcriptional repressor NOT4Hp|
|-20° C, Avoid Freeze/Thaw Cycles|
|312227, 380304, 417936, 4850, 53621, 540891|
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