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Collagen I Rabbit anti-Bovine, Human, Biotin, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA128530

Catalog No. PA128530


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Description

Description

PA1-28530 detects Collagen I from bovine, human samples. PA1-28530 has been successfully used in immunohistochemistry (paraffin tissue), immunoprecipitation, Western blot, and ELISA applications. The PA1-28530 immunogen is collagen type I from adult human and bovine tissues. For extended storage add 50% glycerol, aliquot and store at -20°C or below, avoiding freeze-thaw cycles.

Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. Collagen I is a member of group I collagen (fibril-forming collagen) found in most connective tissues, and is abundant in bone, cornea, dermis and tendon. Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in the COL1A2 gene which codes for the alpha-2 chain, however, tend to be less severe than mutations in the COL1A1 gene, reflecting the different role of alpha-2 chains in matrix integrity. Reciprocal translocations between chromosomes 17 and 22, where Collagen Type 1 genes and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified.
Specifications

Specifications

Collagen I
Polyclonal
Biotin
COL1A1
Liquid
COL1A1
Collagen Type I from adult human and bovine tissues.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Human
ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
1 mg/mL
0.125M sodium borate with 10mg/mL BSA, 5mM EDTA and 0.01% sodium azide; pH 8.0
P02453, Q9XSJ7, P02457, P02452, P11087, P02456, P02454
OI4
Rabbit
IgG
50 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
29393, 100347598, 403651, 1277, 12842, 282187, 395532
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