Collagen I Rabbit anti-Bovine, Human, Biotin, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA128530
PA1-28530 detects Collagen I from bovine, human samples. PA1-28530 has been successfully used in immunohistochemistry (paraffin tissue), immunoprecipitation, Western blot, and ELISA applications. The PA1-28530 immunogen is collagen type I from adult human and bovine tissues. For extended storage add 50% glycerol, aliquot and store at -20°C or below, avoiding freeze-thaw cycles.Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. Collagen I is a member of group I collagen (fibril-forming collagen) found in most connective tissues, and is abundant in bone, cornea, dermis and tendon. Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in the COL1A2 gene which codes for the alpha-2 chain, however, tend to be less severe than mutations in the COL1A1 gene, reflecting the different role of alpha-2 chains in matrix integrity. Reciprocal translocations between chromosomes 17 and 22, where Collagen Type 1 genes and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified.
|Collagen Type I from adult human and bovine tissues.|
|Antigen affinity chromatography|
|ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|0.125M sodium borate with 10mg/mL BSA, 5mM EDTA and 0.01% sodium azide; pH 8.0|
|P02453, Q9XSJ7, P02457, P02452, P11087, P02456, P02454|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|29393, 100347598, 403651, 1277, 12842, 282187, 395532|
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