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Collagen I Rabbit anti-Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA136145

Catalog No. 01-672-101


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Description

Description

Reconstitute with 1 mL of distilled water and add preservative if preferred.

Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. Collagen I is a member of group I collagen (fibril-forming collagen) found in most connective tissues, and is abundant in bone, cornea, dermis and tendon. Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in the COL1A2 gene which codes for the alpha-2 chain, however, tend to be less severe than mutations in the COL1A1 gene, reflecting the different role of alpha-2 chains in matrix integrity. Reciprocal translocations between chromosomes 17 and 22, where Collagen Type 1 genes and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified.
Specifications

Specifications

Collagen I
Polyclonal
Antibody with no preservative
P02454
COL1A1
Purified native collagen type I extracted from rat tail tendon.
Affinity chromatography
RUO
Antibody
Polyclonal
Rat
Dot Blot, ELISA, Immunohistochemistry (Frozen)
Unconjugated
Col1a1
Lyophilized
Rabbit
IgG
100 μg
4° C
Primary
29393
Documents
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