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Complement C4b Chicken anti-Human, Polyclonal, Invitrogen™

Chicken Polyclonal Antibody

Manufacturer:  Invitrogen PA19534

Catalog No. 01-674-417


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Description

Description

PA1-9534 detects C4b complement in human samples. PA1-9534 has been successfully used in Western blot and ELISA procedures. By Western blot, PA1-9534 detects a 88 Kda, 75 Kda, 33 Kda protein representing C4b complement. PA1-9534 immunogen is a purified human C4b complement protein. Store product at 4°C for up to one week and -20°C for long-term.

This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.
Specifications

Specifications

Complement C4b
Polyclonal
Unconjugated
C4B
Liquid
C4B
Purified human C4b complement protein.
IgY fraction
RUO
Antibody
Polyclonal
Human
ELISA, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P0C0L5
C4A, C4A13, C4A91, C4B1, C4B12, C4B2, C4B3, C4B5, C4F, CH, CO4, CPAMD3
Chicken
IgY
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
721
Documents
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