Complement C5a Mouse anti-Human, Clone: 557, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA140160
MA1-40160 detects C5/C5a from human samples. MA1-40160 has been successfully used in ELISA, functional assays and Western blot applications. ELISA: antibody was used as detection antibody in ELISA. The MA1-40160 immunogen is C5/C5a antigen. Endotoxin <24 EU/mg. Positive control: Recombit C5; Negative control: C3.The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Complement fragment C5a is a 74 residue pro-inflammatory polypeptide. C5a is an essential part of the innate immune response and evidence now suggests that it may also play a role in adaptive immunity. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. C5a binds to at least two transmembrane domain receptors, C5aR (C5R1, CD88) and C5L2 (gpr77), expressed ubiquitously on a wide variety of cells but particularly on the surface of immune cells like macrophages, neutrophils and T cells. The widespread expression of C5a receptors throughout the body allows C5a to elicit a broad range of effects. Thus, C5a has been found to be a significant pathogenic driver in a number of immuno-inflammatory diseases. Nowadays C5a is also implicated in non-immunological functions associated with developmental biology, CNS development and neurodegeneration, tissue regeneration, and hematopoiesis.
|PBS with 0.1% BSA and no preservative|
|CPAMD4, FLJ17816, FLJ17822, MGC142298|
|ELISA, Functional Assay, Western Blot|
|BALB/c mice immunized with the human C5/C5a antigen|
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