C5AR1 Mouse anti-Human, Clone: W17/1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA140174
MA1-40174 detects C5aR from human samples. MA1-40174 has been successfully used in flow cytometry and immunohistochemistry (frozen and paraffin) applications. The MA1-40174 immunogen is human C5a receptor.C5AR1 is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. C5AR1 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, C5AR1 stimulates chemotaxis, granule enzyme release and superoxide anion production. C5a is likely a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with C5AR1 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus. All cellular responses to C5a are specifically mediated by interactions with the membrane bound C5a receptor, a seven transmembrane GTP-binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The C5a receptor is approximately 45 kDa.
|PBS with 0.1% BSA and 0.02% sodium azide|
|C5a Receptor, C5A, C5AR, C5R1|
|Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
|Human C5a receptor.|
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