Complement C9 Mouse anti-Human, Clone: X197, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA140186
MA1-40186 detects C9 from human samples. MA1-40186 has been successfully used in flow cytometry, ELISA, functional assays, Western blot, and immunohistochemistry (paraffin and frozen) applications. The MA1-40186 immunogen is the C-terminal region of human C9. Endotoxin <24 EU/mg.Human C9 is a soluble glycoprotein of 61 kD. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. When the complement is activated on target membranes, multiple copies of C9 bind to the C5b-8 complex and assemble the barrel-shaped pore which causes cell lysis. The conformation of C9 changes from globular to a tubular form. The binding of C9 to C5b-8 plays a key role in the function of C9. Mutations in this gene cause component C9 deficiency.
|PBS with 0.1% BSA and no preservative|
|Complement component 9|
|ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot|
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