Connexin 43, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA137496
Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of Connexin43 is known to be regulated by phosphorylation at Ser368 by protein kinase C (Yogo et al., 2002; Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of Connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).This antibody is predicted to react with bovine, canine, mouse, porcine and rabbit based on sequence homology.Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is heart tissue.
|TBS with 1% BSA and <0.1% sodium azide; pH 7.6|
|GJA1, ODDD, Oculodentodigital dysplasia, CX43, DFNB38, Gap junction 43kDa heart protein, SDTY3, Syndactyly type III|
|4° C, do not freeze|
|Synthetic peptide derived from a segment of the 3 cytoplasmic domain of rat connexin 43|
|Antigen affinity chromatography|
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