Coronin 1a Polyclonal Antibody, Invitrogen
Coronin 1a Antibody, PA1-10007, from Invitrogen. Species Reactivity: Human, Mouse, Rat; Applications: Immunocytochemistry, Immunofluorescence, Western Blot.
Manufacturer: Invitrogen PA110007
Coronin 1a Antibody, PA1-10007, from Invitrogen. Species Reactivity: Human, Mouse, Rat; Applications: Immunocytochemistry, Immunofluorescence, Western Blot.Highly conserved coronin family of proteins/actin regulators from WD-repeat superfamily were originally identified in Dictyostelium, wherein, coronin deletions were observed to affect actin-dependent processes, such as phagocytosis, cell motility, and cytokinesis. Coronin-1A (Coro1A) belongs to Type I coronins, almost exclusively expressed in hematopoietic lineages, and plays a key role during T lymphocyte activation, migration, survival, and calcium signaling. Moreover, Coronin-1A has been documented to be dispensable for actin-dependent functions in macrophages. Coro1a-deficient mice have reduced peripheral T cells due to both an impaired survival of naive cells and migrational defects. Both CD4+ and CD8+ T cell subsets are decreased in the periphery of Coro1a-/- mice while thymic cellularity and subpopulations are similar to those observed in wild-type mice. A nonsense mutation in Coro1a has been shown to protect against systemic lupus in a mouse model. Moreover, it has shown that Coro1a is mutated in a thymic egress-deficient mouse strain, but also in a patient with severe combined immunodeficiency (SCID).
Host Species: Chicken
Cross Reactivity: Human, Mouse, Rat
Immunogen: Purified, recombinant human coronin 1a.
Formulation: 100µL purified antibody in PBS and 10mM sodium azide
Synonyms: CLABP, CLIPINA, FLJ41407, HCORO1, MGC117380, TACO, p57
Uniprot Accession: O89053, P31146, Q91ZN1
Entrez GeneID: 11151, 12721, 155151
Gene Symbol: CORO1A
This product detects Coronin 1a in Human, Mouse and Rat samples. This product has been successfully used in Immunocytochemistry, Immunofluorescence and Western Blot procedures. The immunogen is Purified, recombinant human coronin 1a..
|O89053, P31146, Q91ZN1|
|Purified, recombinant human coronin 1a.|
|avoiding freeze/thaw cycles.|
|100μL purified antibody in PBS and 10mM sodium azide|
|CLABP, CLIPINA, FLJ41407, HCORO1, MGC117380, TACO, p57|
|Human, Mouse, Rat|
|11151, 12721, 155151|
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