Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Cortactin Goat anti-Bovine, Canine, Human, Mouse, Rat, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA131469

Catalog No. PIPA131469


Add to cart

Description

Description

PA1-31469 detects Cortactin from human samples. PA1-31469 has been successfully used in Western blot applications. The PA1-31469 immunogen is: Synthetic peptide - amino acids WKASAGHAVSIA of Human Cortactin Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Cortactin (Cttn) is a ubiquitous actin-binding protein that was originally identified as a substrate for Src. It contributes to the organization of the actin cytoskeleton and cell shape. Cortactin also plays a role in the formation of lamellipodia and cell migration. It is accumulated in peripheral, actin-enriched structures of cells suggesting that cortactin facilitates actin network formation. Cortactin has four major domains of interest the N-terminal acidic (NTA) and tandem repeats domains and the C-terminal proline-rich and SH3 Domains. NTA associates with the Arp2/3 and WASP complex at F-actin branches. Cortactin is involved in promoting cell motility and invasion, including a critical role in invadopodia, actin rich-subcellular protrusions associated with degradation of the ECM by cancer cells. Cortactin is phosphorylated by src family kinases at Y421, Y466, and Y482 and S405 and S418 that are phosphorylated by Erk family kinases.
Specifications

Specifications

Cortactin
Polyclonal
Unconjugated
CTTN
Liquid
CTTN
Synthetic peptide corresponding to amino acids WKASAGHAVSIA of Human Cortactin
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Canine, Human, Mouse, Rat
ELISA, Western Blot
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Q14247, Q60598, Q66HL2
EMS1, ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate), Cttn, CORTACTIN, oncogene EMS1
Goat
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
13043, 2017, 506939, 60465, 610283
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit