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Cortisol Sheep anti-Chemical, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen PA185347

Catalog No. PA185347


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Description

Description

PA1-85347 detects Cortisol in The following cross-reactivities have been observed: Cortisol-100%, Corticosterone- >90%. Sheep anti cortisol antibody recognizes the glucocorticoid hormone cortisol, produced in the adrenal cortex and involved in responses to stress. Observed cross reactivities include: Cortisol 100%, Corticosterone >90%.

Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.
Specifications

Specifications

Cortisol
Polyclonal
Unconjugated
Liquid
Cortisol-21-hemisuccinyl-KLH/BSA/Fetuin mixture.
Affinity chromatography
RUO
Antibody
Polyclonal
ELISA
5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Sheep
IgG
1 mL
4°C or -20°C if preferred
Primary
Chemical
Documents
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