CPSF4 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA526623
This antibody is predicted to react with bovine, rat and Xenopus based on sequence homology.Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3 ft. end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3 ft. end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs.
|PBS with 0.09% sodium azide|
|CPSF30, NAR, NEB1, CPSF 30 kDa subunit, NS1 effector domain-binding protein 1, cleavage and polyadenylation specificity factor 30 kDa subunit, cleavage and polyadenylation specificity factor subunit 4, cleavage-polyadenylation specificity factor, 30kD, neb-1, no arches homolog, no|
|-20° C, Avoid Freeze/Thaw Cycles|
|KLH conjugated synthetic peptide between 96-123 amino acids from the central region of human CPSF4|
|Antigen affinity chromatography|
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