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Cripto Rabbit anti-Human, Mouse, DyLight® 550, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA522702

Catalog No. PIPA522702


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Description

Description

In Western blot a band is seen at ~18 kDa representing the core form of Cripto1, and at ~36 kDa reporesenting the glycosylated/ post-translationally modified form. Suggested positive control: MDA-MB231 (human breast cancer) lysates.

Cripto (TDGF1) is a GPI-anchored cell membrane proetin involved in Nodal signaling. Cell associated TDGF1 acts as a a Nodeal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulated Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. TDGF1 is expressed both in ES cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers.
Specifications

Specifications

Cripto
Polyclonal
DyLight™ 550
TDGF1
Liquid
TDGF1
A synthetic peptide made to an N-terminal portion of the murine cripto protein sequence (between residues 1-50).
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Western Blot
0.94 mg/mL
sodium borate with no preservative
P13385, P51865
CR, CRGF, CRIPTO, cripto-1 growth factor, epidermal growth factor-like cripto protein CR1
Rabbit
IgG
100 μL
4° C, store in dark
Primary
21667, 6997
Documents
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