Cripto Rabbit anti-Human, Mouse, HRP, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA522701
In Western blot a band is seen at ~18 kDa representing the core form of Cripto1, and at ~36 kDa reporesenting the glycosylated/ post-translationally modified form. Suggested positive control: MDA-MB231 (human breast cancer) lysates.Cripto (TDGF1) is a GPI-anchored cell membrane proetin involved in Nodal signaling. Cell associated TDGF1 acts as a a Nodeal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulated Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. TDGF1 is expressed both in ES cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers.
|A synthetic peptide made to an N-terminal portion of the murine cripto protein sequence (between residues 1-50).|
|Antigen affinity chromatography|
|PBS with no preservative|
|CR, CRGF, CRIPTO, cripto-1 growth factor, epidermal growth factor-like cripto protein CR1|
|4° C, store in dark|
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