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Crk Mouse, Unlabeled, Clone: 22, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610036

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Catalog No. BDB610036


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Description

Description

Crk was first isolated as the v- crk oncogene from chicken retroviruses CT10 and ASV-1. All human cell lines examined to date express a 40 kDa Crk protein. In addition, there is variable expression of 42 kDa and 28 kDa Crk proteins. The c- crk gene is one of a class of genes, such as Nck and GRB2/ASH , which encode proteins that consist mainly of SH2 and SH3 domains. These proteins function as adaptor molecules in tyrosine kinase signal transduction pathways. The SH2 domains interact with phosphotyrosine-containing peptides, while the SH3 domains can enhance this interaction and/or bind to other cellular components. Both the SH2 and SH3 domains of the human Crk protein are required for differentiation of PC12 cells. Thus, Crk has a role in an NGF-induced signaling pathway that involves activation of p21ras. Furthermore, three proteins of 118 kDa, 125 kDa, and 136 kDa which specifically bind to the Crk SH3 domain have been identified.
Specifications

Specifications

Crk
22
Unconjugated
Affinity Purified
Human Crk aa. 102 to 304
150μg
Cell Biology
Primary
Bovine, Canine, Chicken, Frog, Human, Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG2a
RUO
Store undiluted at -20°C.
Monoclonal
Documents
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