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DRP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520677

Catalog No. PIPA520677


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Description

Description

A suggested positive control is rat brain tissue lysate. PA5-20677 can be used with blocking peptide PEP-0795.

Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity. CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in brain; later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons.
Specifications

Specifications

DRP1
Polyclonal
Unconjugated
CRMP1
Liquid
CRMP1
An 18 amino acid peptide from near the amino terminus of human CRMP1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q14194, P97427, Q62950
CRMP-1, DPYSL1, DRP-1, DRP1, ULIP-3; dihydropyrimidinase related protein-1; dihydropyrimidinase-like 1; dihydropyrimidinase-related protein 1; unc-33-like phosphoprotein 3
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
12933, 1400, 25415
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