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CRYGS Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA524230

Catalog No. PIPA524230

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide,and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. This gene encodes a protein initially considered to be a beta-crystallin but the encoded protein is monomeric and has greater sequence similarity to other gamma-crystallins. This gene encodes the most significant gamma-crystallin in adult eye lens tissue. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.
Specifications

Specifications

CRYGS
Polyclonal
PBS with 0.09% sodium azide
P22914, O35486
CRYG8, beta-crystallin S, crystallin, gamma 8, gamma-S-crystallin, gamma-crystallin S
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
12970, 1427
Western Blot
Unconjugated
CRYGS
Liquid
CRYGS
KLH conjugated synthetic peptide between 133-162 amino acids from the C-terminal region of human CRYGS
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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