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CRYGD Mouse anti-Human, Clone: 2H3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA518655

Catalog No. PIMA518655


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Description

Description

Peptide Sequence: SVRSCRLIPH SGSHRIRLYE REDYRGQMIE FTEDCSCLQD RFRFNEIHSL NVLEGSWVLY ELSNYRGRQY LLMPGDYRRY QDWGATNARV GSLRRVIDFS

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.
Specifications

Specifications

CRYGD
Monoclonal
0.2-1.0 mg/mL
PBS with no preservative; pH 7.4
P07320
Beta4abc
Mouse
IgG1, kappa
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
1421
ELISA, Western Blot
2H3
Unconjugated
CRYGD
Liquid
CRYGD
CRYGD (NP_008822, 75 a.a. ∽ 174 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Documents
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