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GM-CSF Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA524184

Catalog No. PIPA524184


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Description

Description

GM-CSF (Granulocyte-Macrophage colony-stimulating factor) is a 14.6kDa hematopoietic growth factor that exists in glycosylated and non-glycosylated biologically active forms, and stimulates the development of granulocytes, macrophages, early megakaryocytes and eosinophil progenitor cells. The active form of the GM-CSF protein is found extracellularly as a homodimer and the GM-CSF gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q-syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. The ability of recombit GM-CSF to increase hematopoietic cell recovery has become a focus area in the therapeutic treatment of patients following bone marrow transplantation. Recent studies have investigated GM-CSF in inflammatory and autoimmune diseases such as arthritis, arthritis related interstitial lung disease, nephritis, and psoriasis. In the CNS, GM-CSF depletion or neutralization has been studied in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).
Specifications

Specifications

GM-CSF
Polyclonal
Unconjugated
CSF2
Liquid
CSF2
KLH conjugated synthetic peptide between 59-85 amino acids from the central region of human CSF2
Protein A, Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.09% sodium azide
P04141
GMCSF, CSF, colony-stimulating factor, granulocyte-macrophage colony stimulating factor, granulocyte-macrophage colony-stimulating factor, molgramostin, sargramostim
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
1437
Documents
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