CSF2RA Rat anti-Mouse, Clone: 698423, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA523918
In direct ELISAs, no cross-reactivity with recombit human (rh) GM-CSF R alpha orrhGM-CSF R beta is observed. Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.The human IL-3, IL-5 and GM-CSF receptors are each composed of both unique a subunits and a common beta subunit. The a subunits are low affinity ligand binding proteins while the beta subunits do not themselves bind ligand, but are required for high affinity binding by the a subunits. In contrast, the mouse IL-3 receptor has two distinct beta subunits, one that functions only in IL-3 mediated cell signaling and a second that is shared with IL-5 and GM-CSF. The murine beta-subunits are 91% homologous at the amino acid level but only 56% homologous to the human beta subunit. Although neither the murine nor the human beta subunit contains tyrosine kinase domains, both activate tyrosine phosphorylation mediated signaling pathways.
|PBS with 5% trehalose and No Preservative|
|CD116, CD116 antigen, CDw116, Colony stimulating factor 2 receptor alpha chain, CSF 2R, CSF2R, CSF2RA, CSF2RAX, CSF2RAY, CSF2RX, CSF2RY, GM CSF R alpha, GM CSF receptor alpha subunit, GM-CSF-R-alpha, GMCSFR, GMCSFR-alpha, GMR-alpha, Granulocyte-macrophage colony-stimulating factor receptor subunit alpha|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Neutralization|
|Mouse myeloma cell line NS0-derived recombit mouse GM-CSF R alpha Leu30-Pro327|
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