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CSF2RA Rat anti-Mouse, Clone: 698423, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA523918

Catalog No. PIMA523918


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Description

Description

In direct ELISAs, no cross-reactivity with recombit human (rh) GM-CSF R alpha orrhGM-CSF R beta is observed. Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

The human IL-3, IL-5 and GM-CSF receptors are each composed of both unique a subunits and a common beta subunit. The a subunits are low affinity ligand binding proteins while the beta subunits do not themselves bind ligand, but are required for high affinity binding by the a subunits. In contrast, the mouse IL-3 receptor has two distinct beta subunits, one that functions only in IL-3 mediated cell signaling and a second that is shared with IL-5 and GM-CSF. The murine beta-subunits are 91% homologous at the amino acid level but only 56% homologous to the human beta subunit. Although neither the murine nor the human beta subunit contains tyrosine kinase domains, both activate tyrosine phosphorylation mediated signaling pathways.
Specifications

Specifications

CSF2RA
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q00941
CD116, CD116 antigen, CDw116, Colony stimulating factor 2 receptor alpha chain, CSF 2R, CSF2R, CSF2RA, CSF2RAX, CSF2RAY, CSF2RX, CSF2RY, GM CSF R alpha, GM CSF receptor alpha subunit, GM-CSF-R-alpha, GMCSFR, GMCSFR-alpha, GMR-alpha, Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Rat
IgG2A
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
12982
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Neutralization
698423
Unconjugated
Csf2ra
Lyophilized
CSF2RA
Mouse myeloma cell line NS0-derived recombit mouse GM-CSF R alpha Leu30-Pro327
Protein A/G
RUO
Antibody
Monoclonal
Mouse
Documents
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