CSK Goat anti-Human, Mouse, Rat, Polyclonal, Invitrogen™
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA19034
This antibody is predicted to react with bovine and canine based on sequence homology.Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK . This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk .Tissue specificity: Expressed in lung and macrophages.
|Peptide corresponding to the C terminus amino acids EQLEHIKTHELHL.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot|
|TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3|
|P41240, P41241, P32577|
|CSK, c-src tyrosine kinase, MGC117393|
|-20° C, Avoid Freeze/Thaw Cycles|
|12988, 1445, 315707|
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