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COPS8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520539

Catalog No. PIPA520539


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Description

Description

A suggested positive control is human liver tissue lysate. PA5-20539 can be used with blocking peptide PEP-0659.

The COP9 signalosome (CSN) is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-comlpexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.
Specifications

Specifications

COPS8
Polyclonal
Unconjugated
COPS8
Liquid
COPS8
A 15 amino acid peptide near the carboxy terminus of the human CSN8.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q99627, Q8VBV7, Q6P4Z9
COP9, CSN8, SGN8; COP9 homolog; COP9 signalosome complex subunit 8; JAB1-containing signalosome subunit 8; hCOP9; signalosome subunit 8
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
108679, 10920, 363283
Documents
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