CK1 epsilon Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™  

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen 487600

Catalog No. 48-760-0

Description

Casein kinases are a group of ubiquitous Ser/Thr kinases that phosphorylate key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways. CK1 family members share a highly conserved kinase domain but differ in their variable N-and C-terminal domains. Mammals have seven family members: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. They all share at least 50% amino acid identity within the protein kinase catalytic domain. CK1 isoforms exclusively use ATP as phosphate donor and are generally co-factor independent. Casein kinase I epsilon is a Wnt-regulated kinase, and regulated phosphorylation of Dvl allows fine tuning of the Wnt-b-catenin signaling pathway. CKIe positively regulates Akt possibly by inhibiting PP2A. CKIe play an important role in neurodegenerative diseases.

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Specifications

• Antigen: CK1 epsilon
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CSNK1E
• Format: Liquid
• Gene Symbols: CSNK1E
• Immunogen: Synthetic peptide derived from the N-terminal region of the human casein kinase 1 epsilon protein (AccessionNo. NP_689407), which is identical to mouse and rat sequence.
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human, Mouse, Rat

• Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: P49674, Q9JMK2
• Gene Alias: casein kinase 1 epsilon, CK1e, CKIe, RP1-5O6.1, HCKIE, MGC10398 , CKI-epsilon, OTTHUMP00000063258, OTTHUMP00000063263, casein kinase 1 epsilon, casein kinase I epsilon
• Host Species: Rabbit
• Isotype: IgG
• Quantity: 100 μg
• Storage Requirements: -20°C
• Primary or Secondary: Primary
• Gene ID (Entrez): 1454, 27373, 58822