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CK1 epsilon Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen 487600
Description
Casein kinases are a group of ubiquitous Ser/Thr kinases that phosphorylate key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways. CK1 family members share a highly conserved kinase domain but differ in their variable N-and C-terminal domains. Mammals have seven family members: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. They all share at least 50% amino acid identity within the protein kinase catalytic domain. CK1 isoforms exclusively use ATP as phosphate donor and are generally co-factor independent. Casein kinase I epsilon is a Wnt-regulated kinase, and regulated phosphorylation of Dvl allows fine tuning of the Wnt-b-catenin signaling pathway. CKIe positively regulates Akt possibly by inhibiting PP2A. CKIe play an important role in neurodegenerative diseases.This product(s) resides on a Fisher Scientific GSA or VA contract. If you are viewing this page as a nonregistered user, the price(s) displayed is List Price. To view your GSA or VA contract pricing, log in using your account number, or become a registered user by contacting one of our Customer Service teams. You can also view your contract price by searching for this item(s) on GSA Advantage. To place an order, contact Fisher Scientific Customer Service.
Specifications
CK1 epsilon | |
Polyclonal | |
Unconjugated | |
CSNK1E | |
Liquid | |
CSNK1E | |
Synthetic peptide derived from the N-terminal region of the human casein kinase 1 epsilon protein (AccessionNo. NP_689407), which is identical to mouse and rat sequence. | |
Antigen affinity chromatography | |
RUO | |
Antibody | |
Polyclonal | |
Human, Mouse, Rat |
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot | |
0.25 mg/mL | |
PBS with 0.1% sodium azide; pH 7.4 | |
P49674, Q9JMK2 | |
casein kinase 1 epsilon, CK1e, CKIe, RP1-5O6.1, HCKIE, MGC10398 , CKI-epsilon, OTTHUMP00000063258, OTTHUMP00000063263, casein kinase 1 epsilon, casein kinase I epsilon | |
Rabbit | |
IgG | |
100 μg | |
-20°C | |
Primary | |
1454, 27373, 58822 |
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