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CtBP1 (C-terminal Binding Protein-1) Mouse, Unlabeled, Clone: 3, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 612042

Catalog No. BDB612042


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Description

Description

Transcriptional repression is critical for genetic regulation of many cellular proteins, and involves either a transcription regulator that has an intrinsic repressor domain, or a transcription regulator that contains a binding site in the regulatory domain where a corepressor can bind. C-terminal binding proteins (CtBP1 and CtBP2) are a class of corepressors that interact with a subset of transcription factors through a PLDLSL sequence motif. CtBP1 and CtBP2 are 80% homologous, and both are expressed at high levels in embryonic tissues. However, CtBP1 is expressed higher in adult tissues, and is more widely expressed in embryonic and adult tissues. Both CtBP1 and CtBP2 bind the δEF1 zinc finger-homeodomain transcription factor, and enhance transcriptional repression via interaction with the PLDLSL-sequence in δEF1. CtBP1 and CtBP2 bind other zinc finger transcription factors, including Kheper and BKLF. In addition, CtBP2 interacts with other transcription factors, such as hFOG-2, Evi-1, AREB6, and ZEB. Thus, CtBP1 and CtBP2 may be important corepressors for a variety of transcriptional factors.

Host Species: Mouse
Clone: 3
Isotype: IgG1
Species Reactivity [for Features Main]: Mouse
Immunogen: Mouse CtBP1 aa. 345-441

Immunofluorescence, Western Blotting

Specifications

Specifications

CtBP1 (C-terminal Binding Protein-1)
3
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
C-terminal Binding Protein-1
Affinity Purified
Mouse CtBP1 aa. 345-441
50μg
Cell Biology
Primary
Canine, Chicken, Human, Murine, Rat
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