CtBP1 (C-terminal Binding Protein-1) Mouse, Unlabeled, Clone: 3, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 612042

Catalog No. BDB612042

Description

Transcriptional repression is critical for genetic regulation of many cellular proteins, and involves either a transcription regulator that has an intrinsic repressor domain, or a transcription regulator that contains a binding site in the regulatory domain where a corepressor can bind. C-terminal binding proteins (CtBP1 and CtBP2) are a class of corepressors that interact with a subset of transcription factors through a PLDLSL sequence motif. CtBP1 and CtBP2 are 80% homologous, and both are expressed at high levels in embryonic tissues. However, CtBP1 is expressed higher in adult tissues, and is more widely expressed in embryonic and adult tissues. Both CtBP1 and CtBP2 bind the δEF1 zinc finger-homeodomain transcription factor, and enhance transcriptional repression via interaction with the PLDLSL-sequence in δEF1. CtBP1 and CtBP2 bind other zinc finger transcription factors, including Kheper and BKLF. In addition, CtBP2 interacts with other transcription factors, such as hFOG-2, Evi-1, AREB6, and ZEB. Thus, CtBP1 and CtBP2 may be important corepressors for a variety of transcriptional factors.

Host Species: Mouse
Clone: 3
Isotype: IgG1
Species Reactivity [for Features Main]: Mouse
Immunogen: Mouse CtBP1 aa. 345-441

Immunofluorescence, Western Blotting

Specifications

• Antigen: CtBP1 (C-terminal Binding Protein-1)
• Classification: Monoclonal
• Concentration: 250μg/mL
• Description: C-terminal Binding Protein-1
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

• Applications: Western Blot
• Clone: 3
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Mouse CtBP1 aa. 345-441
• Quantity: 50 μg
• Research Discipline: Cell Biology
• Target Species: Canine, Chicken, Human, Mouse, Rat
• Isotype: IgG1