CUEDC2 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523277
DescriptionCUEDC2 is a 287 amino acid protein belonging to the CUEDC2 family with a CUE domain. CUEDC2 is known to interact with PGR and ESR1 with the help of its CUE domain. The exact function of CUEDC2 is yet unknown, but reports suggest that it interacts with PR and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 participates in ubiquitination and subsequent proteasomal degradation of PGR and ESR1 and thus control their protein levels and plays an important role in breast cancer proliferation. Studies on CUEDC2 suggest that it acts as an adaptor protein that interacts with IKK and regulates IKK dephosphorylation by recruiting PP1.
|Synthetic peptide (81 QKLSGQLSDARNKEN 95) of CUEDC2 protein.|
|PBS with 0.05% BSA and 0.05% sodium azide|
|HOYS6, C10orf66, bA18I14.5, CUE domain-containing protein 2|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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