CUEDC2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520620
A suggested positive control is Hela cell lysate. PA5-20620 can be used with blocking peptide PEP-0740.The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, ~40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC2 (CUE domain-containing protein 2) was found through a yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 also decreases the sumoylation of PR. CUEDC2 has also been found to interact with IKK-alpha and IKK-beta and decrease the activation of NF-kappa-B by decreasing the activation of IKK.
|A 19 amino acid peptide from near the carboxy terminus of human CUEDC2.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|Q9H467, Q9CXX9, A1L131|
|HOYS6, C10orf66, bA18I14.5; CUE domain-containing protein 2|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|294009, 67116, 79004|
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