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CUL-2 Mouse, Unlabeled, Clone: 4, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610778

Catalog No. BDB610778

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The cullins are a family of proteins that are integral to cell cycle regulation. Members of this family include human Cul-2, C.elegans Ce-Cul-1, and S. cerevisiae Cdc53. Proper control of cell cycle progression is essential for the prevention of tumorigenesis. Mutant forms of both Ce-Cul-1 and Cdc53 have been implicated in the oncogenic process. Abnormal nuclear localization of Cul-2 is seen in a rare hereditary condition known as VHL (von Hippel-Lindau) syndrome. Patients with VHL syndrome possess a mutant VHL gene and develop cancers such as retinal anginomas, CNS hemangioblastomas, and renal cell carcinomas. In normal cells, the VHL protein competes with subunit A of elongin, a transcription elongation factor, for binding to subunits B and C. The formation of the VHL-B-C complex inhibits elongation. Additional data indicates that this complex associates with CUL-2 and promotes CUL-2 nuclear translocation. In cells with mutated VHL, transcriptional elongation is not efficiently curtailed and CUL-2 is not properly localized in the nucleus. Therefore, CUL-2 mediates VHL function, suggesting CUL-2 may be a candidate human tumor suppressor.

Immunofluorescence, Immunoprecipitation, Western Blotting



Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
Western Blot
Affinity Purified
Human CUL-2 aa. 18-182
Cell Biology
Canine, Human, Murine, Rat
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