Cullin 1, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA121787
Cullin 1 is a member of the family of human cullin genes (CUL 1, 2, 3, 4a, 4b, and 5) homologous to the S. cerevisiae cdc 53 gene. CUL 1 forms a complex with human p19 skp1 and F box protein p45 skp2, both of which, together with cdc 53 (known as CUL A), as three subunits form a ubiquitin ligase controlling proteolysis of G1 cell cycle regulatory proteins. The CUL 1/p19 skp1/p45 skp2complex is thought to play a role in the ubiquitination of G1 regulatory proteins.PA1-21787 detects Cullin 1 in human and mouse samples. This antibody does not cross-react with rat Cullin 1.PA1-21787 has been successfully used in immunohistochemistry (FFPE), immunoprecipitation and Western Blot procedures. No special pretreatment is required for immunostaining of formalin-fixed paraffin-embedded tissue sections.The PA1-21787 immunogen is a synthetic peptide corresponding to residues C-D(742) G E K D T Y S Y L A(752) of human Cullin 1.
|Synthetic peptide corresponding to residues C-D(742) G E K D T Y S Y L A(752) of human Cullin 1.|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4|
|Store at 4°C|
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