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CX3CL1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520296

Catalog No. PIPA520296


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Description

Description

Despite the predicted molecular weight, CX3CL1 often migrates at 80-100kDa in SDS-PAGE, presumably due to post-translational modifications. A suggested positive control is C2C12 cell lysate. PA5-20296 can be used with blocking peptide PEP-0398.

Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.
Specifications

Specifications

CX3CL1
Polyclonal
PBS with 0.02% sodium azide
P78423, O35188
CX3CL1
A peptide corresponding to 18 amino acids near the amino terminus of human CX3CL1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunoprecipitation, Western Blot
Unconjugated
CX3CL1
Liquid
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
20312, 6376
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