CX3CL1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520296
Despite the predicted molecular weight, CX3CL1 often migrates at 80-100kDa in SDS-PAGE, presumably due to post-translational modifications. A suggested positive control is C2C12 cell lysate. PA5-20296 can be used with blocking peptide PEP-0398.Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.
|PBS with 0.02% sodium azide|
|A peptide corresponding to 18 amino acids near the amino terminus of human CX3CL1.|
|Antigen affinity chromatography|
|Immunoprecipitation, Western Blot|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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