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CXCR2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA131217

Catalog No. PA131217


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Description

Description

PA1-31217 detects CXCR2 from human, mouse, and rat samples. PA1-31217 has been successfully used in immunohistochemistry (frozen tissue), immunoprecipitation, and Western blot applications. Predicted molecular weight of 55 kDa. The PA1-31217 immunogen is synthetic peptide (selective for CXCR2 receptor +C-terminal region)

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
Specifications

Specifications

CXCR2
Polyclonal
Unconjugated
CXCR2
Liquid
CXCR2
Synthetic peptide (selective for CXCR2 receptor +C-terminal region)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
0.75 mg/mL
antibody with 0.02% sodium azide
P25025, P35343, P35407
CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
12765, 29385, 3579
Documents
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